Yes, he will absolutely refuse all motions of help and let Spock sit in his comfy chair more.

"You would assume correctly. No effect? I know of many humans who would like that little quirk." Well, perhaps the after effects would be more accurate. Even Pike has wanted to skip the hangover sometimes.

"Care for a martini, then? They're not as good as Dr. Boyce's, I'm afraid, but they'll do." He will actually wait for Spock to answer before dialing up a drink for him, but he's already getting one for himself.